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7. Total Net Revenues from Our Continuing Operations

Supply revenues

These revenues are fully related to the supply of Jyseleca® to Alfasigma under the transition agreement. The related cost of sales are reported on the cost of sales line.

Collaboration revenues

The following table summarizes our collaboration revenues for the years ended December 31, 2025 and 2024 by collaboration and by category of revenue: upfront payments and license fees, and royalties.

Collaboration revenues by category

 

Year ended December 31

(thousands of €)

Over time

Point in time

2025

2024

Recognition of non-refundable upfront payments and license fees

 

 

1,070,147

230,182

Gilead collaboration agreement for drug discovery platform

 

1,068,967

230,182

Cartilla Therapeutics GLPG1972

 

1,180

 

 

 

 

 

 

Royalties

 

 

12,177

10,604

Gilead royalties on Jyseleca®

 

12,177

10,604

 

 

 

 

 

Total collaboration revenues

 

 

1,082,324

240,786

We refer to note 2 of this financial report for a general description of our collaboration with Gilead. On December 31, 2025, as a result of the OLCA amendments and other events in 2025, the contract liability of €1,069.0 million reported on December 31, 2024 with respect to the OLCA has been derecognized and released as revenue in 2025. We refer to note 4 of this financial report for further details.

For the year ended December 31, 2025 we recognized in revenue €12.2 million of royalties from Gilead on filgotinib. The royalties on sales of Jyseleca® performed by Gilead in Japan were not reported as discontinued operations as we still have the right to receive those royalties on future sales made by Gilead and its commercialization partners (this right is not subject to transfer to Alfasigma as part of the transfer of the Jyseleca® business to them).

Filgotinib
Small molecule preferential JAK1 inhibitor, approved in RA and UC in the European Union, Great-Britain and Japan, and marketed under the brand name Jyseleca®. The Jyseleca® business has been transferred to AlfaSigma in 2024
Jyseleca®
Brand name for filgotinib